Article
Effects of ligand binding on the association properties and conformation in solution of retinoic acid receptors RXR and RAR.
Journal of molecular biology - 23 Mar 2001
Egea P F, Rochel N, Birck C, Vachette P, Timmins P A, Moras D
Abstract excerpt
In higher eukaryotes, vitamin A derived metabolites such as 9-cis and all-trans retinoic acid (RA), are involved in the regulation of several essential physiological processes. Their pleiotropic physiological effects are mediated through direct binding to cognate nuclear receptors RXRs and RARs that act as regulated transcription factors belonging to the superfamily of nuclear hormone receptors. Hormone binding...
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