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Distinct and Shared Impacts of Virulence Plasmids on the Phenotype and Transcriptome in Convergent Carbapenem-Resistant and Hypervirulent <i>Klebsiella pneumoniae</i>

2025-11-10

Abstract excerpt

<h4>ABSTRACT</h4> The global rise of convergent carbapenem-resistant and hypervirulent Klebsiella pneumoniae (CR-hvKp) represents a major clinical challenge, yet the role of virulence plasmids (pVirs) in shaping bacterial physiology and pathogenicity remains incompletely understood. Using a CRISPR-Cas9–based curing system, we precisely eliminated pVirs from two clinical CR-hvKp strains with distinct genetic back...

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Literature Corpus work
82efcc33-0a7f-53b5-9cfa-f890a8b04cd1
DOI
10.1101/2025.11.10.687661
Open publication

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Distinct and Shared Impacts of Virulence Plasmids on the Phenotype and Transcriptome in Convergent Carbapenem-Resistant and Hypervirulent <i>Klebsiella pneumoniae</i>DOI 10.1101/2025.11.10.687661
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