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Article

Distinct and shared impacts of virulence plasmids on the phenotype and transcriptome in convergent carbapenem-resistant and hypervirulent Klebsiella pneumoniae.

Microbiology spectrum - 7 Jul 2026

Hao Mingju, Cui Xiaodi, Feng Liya, Liu Ke, Shi Xiaohong, Long Tengfei, Rowe Sarah E, Lin Yi-Tsung, Chen Liang

Abstract excerpt

The global rise of convergent carbapenem-resistant and hypervirulent Klebsiella pneumoniae (CR-hvKp) represents a major clinical challenge, yet the role of virulence plasmids (pVirs) in shaping bacterial physiology and pathogenicity remains incompletely understood. Using a CRISPR-Cas9-based curing system, we precisely eliminated pVirs from two clinical CR-hvKp strains, sequence type 23 (ST23)-KL1 (blaNDM-1) and...

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Identifiers

PMID: 42262135
DOI: 10.1128/spectrum.04174-25
PMCID: PMC13340312

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