Decoding Hypervirulence in Carbapenem-Resistant Klebsiella pneumoniae: Genomic and Phenotypic Profiling Reveals Capsular Polysaccharide as a Key Driver of Pathogenicity.

doi:10.1093/infdis/jiag075

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Article

Decoding Hypervirulence in Carbapenem-Resistant Klebsiella pneumoniae: Genomic and Phenotypic Profiling Reveals Capsular Polysaccharide as a Key Driver of Pathogenicity.

The Journal of infectious diseases - 15 May 2026

Xu Li, Li Jiayang, Wu Wenqi, Dou Liuqing, Wang Jiajie, Qiu Mingjie, Zhou Zhitao, Tian Sai, Wu Meilin, Zhu Yeting, Ma Rui, Yang Shuanghong, Hong Zhiwu, Ren Jianan, Wu Xiuwen

Abstract excerpt

BACKGROUND: The global dissemination of hypervirulent carbapenem-resistant Klebsiella pneumoniae (hv-CRKP) poses escalating threats to public health. Substantial controversy persists regarding its true virulence potential, highlighting the need for reliable biomarkers to enable early diagnosis and targeted therapy. METHODS: Using a mouse subcutaneous challenge model, we characterized 59 carbapenem-resistant K....

Topics

Klebsiella pneumoniae
Animals
Klebsiella Infections
Virulence
Mice
Humans
Bacterial Capsules
Female
Carbapenems
Carbapenem-Resistant Enterobacteriaceae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome-Wide Association Study

Phenotype

Polysaccharides, Bacterial

Genomics

Disease Models, Animal

Anti-Bacterial Agents

Male

Gene Expression Profiling

Source

Open in PubMed

Identifiers

PMID: 41662361
DOI: 10.1093/infdis/jiag075

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-41662361-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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