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Phenotypic and genomic characterization of ST11-K1 CR-hvKP with highly homologous blaKPC-2-bearing plasmids in China.

mSystems - 17 Dec 2024

Han Yu-Ling, Wang Hua, Zhu Hong-Zhe, Lv Ying-Ying, Zhao Wen, Wang Yan-Yan, Wen Jian-Xun, Hu Zhi-De, Wang Jun-Rui, Zheng Wen-Qi

Abstract excerpt

Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) strains present a significant global public health threat due to their high mortality rates. This study investigated the genomic characteristics of seven ST11-K1 CR-hvKP isolates harboring highly homologous KPC-2-encoding multidrug-resistance plasmids. The strains were isolated from a Chinese tertiary hospital between 2017 and 2020. Whole-genome...

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Identifiers

PMID: 39555910
DOI: 10.1128/msystems.01101-24
PMCID: PMC11651102

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