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Article

Adaptive attenuation of virulence in hypervirulent carbapenem-resistant Klebsiella pneumoniae.

mSystems - 18 Jun 2024

Teng Gaoqin, Zhang Meng, Fu YingYing, Yang Xiaoqiang, Kang Yanhua, Qin Qiuying, Jin Ye, Huang Man, Xu Yongchang

Abstract excerpt

The emergence of nosocomial infections caused by hypervirulent and carbapenem-resistant K. pneumoniae (hv-CRKP) has become a significant public health challenge. The genetic traits of virulence and resistance plasmids in hv-CRKP have been extensively studied; however, research on the adaptive evolution strategies of clinical strains inside the host was scarce. This study aimed to understand the effects of...

Topics

Klebsiella pneumoniae
Virulence
Humans
Klebsiella Infections
Promoter Regions, Genetic
Carbapenems
Animals
Anti-Bacterial Agents
Mice
Carbapenem-Resistant Enterobacteriaceae
Biofilms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Bacterial Proteins

Polymorphism, Single Nucleotide

Cross Infection

Source

Open in PubMed Open full text

Identifiers

PMID: 38752758
DOI: 10.1128/msystems.01363-23
PMCID: PMC11237801

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-38752758-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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