Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Virulence phenotype first: a framework for assessing the clinical risk of resistance-hypervirulence convergence in Klebsiella pneumoniae.

Science bulletin - 30 Jun 2026

Zhao Jiankang, Pu Danni, Syed Muhammad Ali, Song Rongrong, Fan Yanyan, Liu Yan, Cao Bin

Abstract excerpt

Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) marks a pivotal evolutionary shift in which antimicrobial resistance and hypervirulence increasingly co-exist within the same lineages. Evidence supports two dominant convergence routes, hypervirulent backgrounds acquiring resistance modules and carbapenem-resistant classical backbones acquiring virulence modules, followed by diversification into...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Carbapenems

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance, Bacterial

Share to Klebsiella Infections

Share to Klebsiella pneumoniae

Share to Phenotype

Share to Virulence

Source

Identifiers

PMID: 42191476
DOI: 10.1016/j.scib.2026.05.027

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Virulence phenotype first: a framework for assessing the clinical risk of resistance-hypervirulence convergence in Klebsiella pneumoniae.PMID 42191476Read ↗

Emergence of Dual-Risk <i>Klebsiella pneumoniae</i> : Global Hotspots of Convergence Between Resistance and HypervirulenceSemantic proximity Read ↗

Decoding Hypervirulence in Carbapenem-Resistant Klebsiella pneumoniae: Genomic and Phenotypic Profiling Reveals Capsular Polysaccharide as a Key Driver of Pathogenicity.Semantic proximity Read ↗

Distinct and Shared Impacts of Virulence Plasmids on the Phenotype and Transcriptome in Convergent Carbapenem-Resistant and Hypervirulent <i>Klebsiella pneumoniae</i>Semantic proximity Read ↗

Hypermucoviscosity in Klebsiella pneumoniae: manifestation, regulation, and roles in pathogenesis.Semantic proximity Read ↗

Distinct and shared impacts of virulence plasmids on the phenotype and transcriptome in convergent carbapenem-resistant and hypervirulent Klebsiella pneumoniae.Semantic proximity Read ↗

A preclinical resistance framework discovers the virulence risks of antibiotics in developmentSemantic proximity Read ↗

Acquisition of Strain-Specific Fragment and Capsular-Biofilm Traits Drives Host Adaptation and Resistance Evolution in Hypervirulent Carbapenem-Resistant Klebsiella pneumoniaeSemantic proximity Read ↗

A Decade-Long Review of the Virulence, Resistance, and Epidemiological Risks of <em>Klebsiella pneumoniae </em>in ICUsSemantic proximity Read ↗

In-host evolution of classic to convergent <i>Klebsiella pneumoniae</i> sequence type 147 isolates and impact of associated capsular changes on different morphotypesSemantic proximity Read ↗

A global perspective on the convergence of hypervirulence and carbapenem resistance in Klebsiella pneumoniaeSemantic proximity Read ↗

Three Plasmid Strategies, One Intermediate Convergence State: Lineage-Specific Resistance–Virulence Architecture in Dominant Indian Carbapenem-Resistant <i>Klebsiella pneumoniae</i> ClonesSemantic proximity Read ↗

Differentiation of hypervirulent and classical <i>Klebsiella pneumoniae</i> with acquired drug resistanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.