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<i>BRCA</i> mutational status shapes the stromal microenvironment of pancreatic cancer linking CLU <sup>+</sup> CAF expression with HSF1 signaling

2021-08-19

Abstract excerpt

Cancer-associated fibroblasts (CAFs) give rise to desmoplastic stroma, which supports tumor progression and metastasis, and comprises up to 90% of the tumor mass in pancreatic cancer. Recent work by us and others has shown that CAFs are transcriptionally rewired by adjacent cancer cells to form heterogeneous subtypes. Whether this rewiring is differentially affected by different driver mutations in cancer cells is...

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Literature Corpus work
82eaa595-3ece-530f-ae62-c812f0cc256a
DOI
10.1101/2021.08.18.456576
Open publication

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<i>BRCA</i> mutational status shapes the stromal microenvironment of pancreatic cancer linking CLU <sup>+</sup> CAF expression with HSF1 signalingDOI 10.1101/2021.08.18.456576
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