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Article

Hypoxic microenvironment determines the phenotypic plasticity and spatial distribution of cancer‐associated fibroblasts

1 Oct 2023

Abstract excerpt

Recent single-cell RNA-sequencing (scRNA-seq) techniques have corroborated a previously unappreciated cancer-associated fibroblast (CAF) heterogeneity in multiple cancer types.1 Among several CAF subtypes, myofibroblastic CAFs (myCAFs) and inflammatory CAFs (iCAFs) are consistently observed across various cancer types and constitute major CAF populations.2 To date, it has been regarded that certain CAF subtypes...

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PMID: 37837402
DOI: 10.1002/ctm2.1438

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