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Article

Substrate recognition and processing by a Walker B mutant of the human mitochondrial AAA+ protein CLPX.

Journal of structural biology - 1 Aug 2012

Lowth Bradley R, Kirstein-Miles Janine, Saiyed Tamanna, Brötz-Oesterhelt Heike, Morimoto Richard I, Truscott Kaye N, Dougan David A

Abstract excerpt

The mitochondrial matrix of mammalian cells contains several different ATP-dependent proteases, including CLPXP, some of which contribute to protein maturation and quality control. Currently however, the substrates and the physiological roles of mitochondrial CLPXP in humans, has remained elusive. Similarly, the mechanism by which these ATP-dependent proteases recognize their substrates currently remains unclear....

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Source

Identifiers

PMID: 22710082
DOI: 10.1016/j.jsb.2012.06.001

Genes

CLPX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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