Article

Human lung organoids develop into adult airway-like structures directed by physico-chemical biomaterial properties

2019-02-28

Abstract excerpt

Tissues derived from human pluripotent stem cell (hPSC) often represent early developmental time points. Yet, when transplanted into immunocompromised mice, these hPSC-derived tissues further mature, which has been enhanced with biomaterial scaffolds, gaining tissue structure and cell types similar to the native adult lung. Our goal was to define the physico-chemical biomaterial properties, including the polymer t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 82bae3d7-6658-56ae-920a-b4e6e1ddb2d3
DOI: 10.1101/564252

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human lung organoids develop into adult airway-like structures directed by physico-chemical biomaterial propertiesDOI 10.1101/564252Read

Microstructured hydrogels to guide self-assembly and function of lung alveolospheresSemantic proximity Read

hPSC-derived lung organoids: Potential opportunities and challengesSemantic proximity Read

Organoids as a model system for studying human lung development and disease.Semantic proximity Read

Short‐Term Preclinical Application of Functional Human Induced Pluripotent Stem Cell‐Derived Airway Epithelial PatchesSemantic proximity Read

Development of a Three-Dimensional Bioengineering Technology to Generate Lung Tissue for Personalized Disease Modeling.Semantic proximity Read

Biomaterial-based 3D human lung models replicate pathological characteristics of early pulmonary fibrosisSemantic proximity Read

Bioinspired Hydrogels for 3D Organoid CultureSemantic proximity Read

How to Grow a Lung: Applying Principles of Developmental Biology to Generate Lung Lineages from Human Pluripotent Stem CellsSemantic proximity Read

Human Lung Spheroids as In Vitro Niches of Lung Progenitor Cells with Distinctive Paracrine and Plasticity Properties.Semantic proximity Read

Integrated mesenchymal and extracellular cues drive bioengineered liver tissue formation and functionSemantic proximity Read

Transitional alveolar epithelial cells and microenvironmental stiffness synergistically drive fibroblast activation in three-dimensional hydrogel lung modelsSemantic proximity Read

Matrix-free human lung organoids derived from induced pluripotent stem cells to model lung injurySemantic proximity Read