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Matrix-free human lung organoids derived from induced pluripotent stem cells to model lung injury

18 Dec 2024

Abstract excerpt

BACKGROUND: Organoids, as near-physiological 3D culture systems, offer new opportunities to study the pathogenesis of various organs in mimicking the cellular complexity and functionality of human organs. METHOD: Here we used a quite simple and very practicable method to successfully generate induced pluripotent stem cell (iPSC)-derived human lung organoids (LuOrg) in a matrix-free manner as an alternative to the...

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PMID: 39696649
DOI: 10.1186/s13287-024-04106-3

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