Article

Genetic Mapping of Monocyte Fate Decisions Following Myocardial Infarction

2023-12-25

Abstract excerpt

Inflammation contributes to the pathogenesis of myocardial infarction and heart failure and represents a viable therapeutic target. Monocytes and their progeny are highly abundant and display incredible functional diversity, serving as key determinants of myocardial inflammation and tissue repair. Much remains to be learned regarding mechanisms and signaling events that instruct monocyte fate decisions. We devised...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 82a378fa-d2ed-5442-8501-59b1ee212375
DOI: 10.1101/2023.12.24.573263

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic Mapping of Monocyte Fate Decisions Following Myocardial InfarctionDOI 10.1101/2023.12.24.573263Read

Dynamics of monocyte-derived macrophage diversity in experimental myocardial infarctionSemantic proximity Read

Ly6C <sup>hi</sup> monocytes are metabolically reprogrammed in the blood during inflammatory stimulation allowing for macrophage lineage commitmentSemantic proximity Read

Hypoxia sensing in resident cardiac macrophages regulates monocyte fate specification following ischemic heart injury.Semantic proximity Read

Fate mapping via Ms4a3 expression history traces monocyte-derived cellsSemantic proximity Read

Monocyte and Macrophage Heterogeneity in the HeartSemantic proximity Read

Acute myocardial infarction activates distinct inflammation and proliferation pathways in circulating monocytes, prior to recruitment, and identified through conserved transcriptional responses in mice and humans.Semantic proximity Read

Genomic Characterization of Murine Monocytes Reveals C/EBPβ Transcription Factor Dependence of Ly6C- Cells.Semantic proximity Read

Monocyte Single-Cell Multimodal Profiling in Cardiovascular Disease Risk StatesSemantic proximity Read

Spatiotemporal dynamics of macrophage heterogeneity and a potential function of Trem2hi macrophages in infarcted heartsSemantic proximity Read

Dissecting and Visualizing the Functional Diversity of Cardiac MacrophagesSemantic proximity Read

Using High-Dimensional Approaches to Probe Monocytes and Macrophages in Cardiovascular DiseaseSemantic proximity Read

Single-cell multiomic analysis identifies macrophage subpopulations in promoting cardiac repairSemantic proximity Read