Article
Hypoxia sensing in resident cardiac macrophages regulates monocyte fate specification following ischemic heart injury.
Nature cardiovascular research - 1 Nov 2024
Kadyrov Farid F, Koenig Andrew L, Amrute Junedh M, Dun Hao, Li Wenjun, Weinheimer Carla J, Nigro Jessica M, Kovacs Attila, Bredemeyer Andrea L, Yang Steven, Das Shibali, Penna Vinay R, Parvathaneni Alekhya, Lai Lulu, Hartmann Niklas, Kopecky Benjamin J, Kreisel Daniel, Lavine Kory J
Abstract excerpt
Myocardial infarction initiates cardiac remodeling and is central to heart failure pathogenesis. Following myocardial ischemia-reperfusion injury, monocytes enter the heart and differentiate into diverse subpopulations of macrophages. Here we show that deletion of Hif1α, a hypoxia response transcription factor, in resident cardiac macrophages led to increased remodeling and overrepresentation of macrophages...
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