Acute myocardial infarction activates distinct inflammation and proliferation pathways in circulating monocytes, prior to recruitment, and identified through conserved transcriptional responses in mice and humans.

doi:10.1093/eurheartj/ehv195

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Article

Acute myocardial infarction activates distinct inflammation and proliferation pathways in circulating monocytes, prior to recruitment, and identified through conserved transcriptional responses in mice and humans.

European heart journal - 1 Aug 2015

Ruparelia Neil, Godec Jernej, Lee Regent, Chai Joshua T, Dall'Armellina Erica, McAndrew Debra, Digby Janet E, Forfar J Colin, Prendergast Bernard D, Kharbanda Rajesh K, Banning Adrian P, Neubauer Stefan, Lygate Craig A, Channon Keith M, Haining Nicholas W, Choudhury Robin P

Abstract excerpt

AIMS: Monocytes play critical roles in tissue injury and repair following acute myocardial infarction (AMI). Specifically targeting inflammatory monocytes in experimental models leads to reduced infarct size and improved healing. However, data from humans are sparse, and it remains unclear whether monocytes play an equally important role in humans. The aim of this study was to investigate whether the monocyte...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25982896
DOI: 10.1093/eurheartj/ehv195
PMCID: PMC4571177

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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