Article

Identification of outcome-related driver mutations in cancer using conditional co-occurrence distributions

2016-09-16

Abstract excerpt

The methods proposed for the detection of cancer driver mutations are based on the estimation of background mutation rate, impact on protein function, or network influence. Instead, we focus on those influencing patient survival. For this, an approximation of the log-rank test has been systematically applied even though it assumes a large and similar number of patients in both risk groups, which is violated in can...

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Literature Corpus work: 829c1b41-e570-5d39-84b4-d1dd9f406493
DOI: 10.1101/075408

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