Article
VALORATE: fast and accurate log-rank test in balanced and unbalanced comparisons of survival curves and cancer genomics.
Bioinformatics (Oxford, England) - 15 Jun 2017
Treviño Victor, Tamez-Pena Jose
Abstract excerpt
SUMMARY: The association of genomic alterations to outcomes in cancer is affected by a problem of unbalanced groups generated by the low frequency of alterations. For this, an R package (VALORATE) that estimates the null distribution and the P -value of the log-rank based on a recent reformulation is presented. For a given number of alterations that define the size of survival groups, the log-rank density is...
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