Article

Codon affinity in mitochondrial DNA shapes evolutionary and somatic fitness

2023-04-23

Abstract excerpt

<h4>Summary Paragraph</h4> Somatic variation contributes to biological heterogeneity by modulating cellular proclivity to differentiate, expand, adapt, or die. While large-scale sequencing efforts have revealed the foundational role of somatic variants to drive human tumor evolution, our understanding of the contribution of mutations to modulate cellular fitness in non-malignant contexts remains understudied. Her...

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Literature Corpus work: 48ccfb62-4748-587f-812e-79becd0dbe60
DOI: 10.1101/2023.04.23.537997

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