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<i>Dyrk1a</i> gene dosage in glutamatergic neurons has key effects in cognitive deficits observed in mouse models of MRD7 and Down syndrome

2021-05-01

Abstract excerpt

Perturbation of the excitation/inhibition (E/I) balance leads to neurodevelopmental diseases including to autism spectrum disorders, intellectual disability, and epilepsy. Mutation in the DYRK1A gene located on human chromosome 21 (Hsa21) leads to an intellectual disability syndrome associated with microcephaly, epilepsy, and autistic troubles (MRD7). Overexpression of DYRK1A, on the other hand, has been linked w...

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Literature Corpus work
51eac287-ce8a-51d2-bb5e-87343e2066fa
DOI
10.1101/2021.05.01.442242
Open publication

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<i>Dyrk1a</i> gene dosage in glutamatergic neurons has key effects in cognitive deficits observed in mouse models of MRD7 and Down syndromeDOI 10.1101/2021.05.01.442242
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