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<i>C9orf72</i> -associated G4C2 hexanucleotide repeat expression in <i>Drosophila</i> mushroom bodies causes age dependent TDP-43 pathology and dementia relevant phenotypes mediated in part by the glypican Dlp/GPC6

2026-05-12

Abstract excerpt

Hexanucleotide repeat expansions (HREs) in C9orf72 are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), yet the age-, sex-, repeat-length-, and circuit-specific influence on the pathology of neurons remains incompletely understood. Here, we established a Drosophila model of C9orf72 -associated dementia by expressing G4C2 repeats in mushroom body neurons (MB...

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Literature Corpus work
17ed101b-2f90-5b88-a550-954d956af5cf
DOI
10.64898/2026.05.08.723849
Open publication

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<i>C9orf72</i> -associated G4C2 hexanucleotide repeat expression in <i>Drosophila</i> mushroom bodies causes age dependent TDP-43 pathology and dementia relevant phenotypes mediated in part by the glypican Dlp/GPC6DOI 10.64898/2026.05.08.723849
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