Article

β-Catenin Stabilization Protects Against Pulmonary Hemorrhage Through Amphiregulin and BATF- Mediated Regulatory T Cells

2025-10-22

Abstract excerpt

Pulmonary hemorrhaging (PH) is a life-threatening condition with a high mortality rate, yet the role of immune cells in its pathogenesis remains poorly defined. Here, we investigated the protective function of β-catenin stabilization in T cells and its impact on PH. Using a novel transgenic mouse model (CAT-Tg) with stabilized β-catenin, we demonstrate that β-catenin stabilization induces a distinct T-cell phenoty...

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Identifiers and source

Literature Corpus work: 82553382-8a3a-58c3-bf43-9c2cb2872a22
DOI: 10.1101/2025.10.21.683678

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