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Article

The common Sting1 HAQ, AQ alleles rescue CD4 T cellpenia, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice.

eLife - 18 Sept 2024

Aybar-Torres Alexandra A, Saldarriaga Lennon A, Pham Ann T, Emtiazjoo Amir M, Sharma Ashish K, Bryant Andrew J, Jin Lei

Abstract excerpt

The significance of STING1 gene in tissue inflammation and cancer immunotherapy has been increasingly recognized. Intriguingly, common human STING1 alleles R71H-G230A-R293Q (HAQ) and G230A-R293Q (AQ) are carried by ~60% of East Asians and ~40% of Africans, respectively. Here, we examine the modulatory effects of HAQ, AQ alleles on STING-associated vasculopathy with onset in infancy (SAVI), an autosomal dominant,...

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Identifiers

PMID: 39291958
DOI: 10.7554/eLife.96790
PMCID: PMC11410371

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