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Article

DLL4/Notch1 and BMP9 Interdependent Signaling Induces Human Endothelial Cell Quiescence via P27KIP1 and Thrombospondin-1.

Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2015

Rostama Bahman, Turner Jacqueline E, Seavey Guy T, Norton Christine R, Gridley Thomas, Vary Calvin P H, Liaw Lucy

Abstract excerpt

OBJECTIVE: Bone morphogenetic protein-9 (BMP9)/activin-like kinase-1 and delta-like 4 (DLL4)/Notch promote endothelial quiescence, and we aim to understand mechanistic interactions between the 2 pathways. We identify new targets that contribute to endothelial quiescence and test whether loss of Dll4(+/-) in adult vasculature alters BMP signaling. APPROACH AND RESULTS: Human endothelial cells respond...

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Source

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Identifiers

PMID: 26471266
DOI: 10.1161/ATVBAHA.115.306541
PMCID: PMC4662626

Genes

DLL4
HEY1
HEY2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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