Article

Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis

2018-12-20

Abstract excerpt

Genome-wide association studies (GWAS) have identified thousands of variants associated with human diseases and traits. However, the majority of GWAS-implicated variants are in non-coding genomic regions and require in depth follow-up to identify target genes and decipher biological mechanisms. Here, rather than focusing on causal variants, we have undertaken a pooled loss-of-function screen in primary hematopoiet...

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Literature Corpus work: d1f8befa-a4bd-514a-a606-aedec681a4c5
DOI: 10.1101/500579

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