Article

Single-nucleus analysis reveals oxidative stress in Down syndrome basal forebrain neurons at birth

2025-02-06

Abstract excerpt

<h4>INTRODUCTION</h4> Basal forebrain cholinergic neurons (BFCNs) are integral to learning, attention, and memory, and are prone to degeneration in Down syndrome (DS), Alzheimer’s disease, and other neurodegenerative diseases. However, the mechanisms that lead to the degeneration of these neurons are not known. <h4>METHODS</h4> Single-nucleus gene expression and ATAC sequencing were performed on postmortem human...

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Literature Corpus work: 824ae738-ea9c-55e2-b638-2279f8916316
DOI: 10.1101/2025.02.05.636750

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