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Single-nucleus transcriptome atlas of the basal forebrain reveals diverse ageing-related pathways

12 Feb 2025

Abstract excerpt

The basal forebrain is a critical brain region involved in various neurobiological processes, including learning, memory and attention. Basal forebrain cells undergo structural and functional changes during ageing, increasing their vulnerability to neurodegenerative diseases. To reveal the molecular landscape of distinct cell types during development and early ageing, we constructed a comprehensive single-nucleus...

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PMID: 39936500
DOI: 10.1093/brain/awaf060

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