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Profiling Basal Forebrain Cholinergic Neurons Reveals a Molecular Basis for Vulnerability Within the Ts65Dn Model of Down Syndrome and Alzheimer’s Disease

2020-10-09

Abstract excerpt

<title>Abstract</title> <p>Background: Basal forebrain cholinergic neuron (BFCN) degeneration is a hallmark of Down syndrome (DS) and Alzheimer’s disease (AD). Current therapeutics have been unsuccessful in slowing disease progression, likely due to complex pathological interactions and dysregulated pathways that are poorly understood. The Ts65Dn trisomic mouse model recapitulates both cognitive and morphological...

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Literature Corpus work
4f69dc4c-e747-56a4-9f03-3a592339389e
DOI
10.21203/rs.3.rs-88218/v1
Open publication

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Profiling Basal Forebrain Cholinergic Neurons Reveals a Molecular Basis for Vulnerability Within the Ts65Dn&nbsp;Model of Down Syndrome and Alzheimer’s DiseaseDOI 10.21203/rs.3.rs-88218/v1
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