Article

Cooperative Genomic Lesions in HRAS-Mutant Cancers Predict Resistance to Farnesyltransferase Inhibitors

2023-07-14

Abstract excerpt

<title>Abstract</title> <p>The clinical development of farnesyltransferase inhibitors (FTI) for <italic>HRAS</italic>-mutant tumors showed mixed responses dependent on cancer type. Co-occurring mutations may affect response. We aimed to uncover cooperative genetic events specific to <italic>HRAS</italic>-mutant tumors and study their effect on FTI sensitivity. Using targeted sequencing data from MSK-IMPACT and DF...

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Literature Corpus work: 81ff3949-6fdc-5972-8fa1-931ace0da04a
DOI: 10.21203/rs.3.rs-3154719/v1

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