Article
Efficacy of immunotherapy in lung cancer with co-occurring mutations in NOTCH and homologous repair genes.
Journal for immunotherapy of cancer - 1 Aug 2020
Mazzotta Marco, Filetti Marco, Occhipinti Mario, Marinelli Daniele, Scalera Stefano, Terrenato Irene, Sperati Francesca, Pallocca Matteo, Rizzo Francesco, Gelibter Alain, Botticelli Andrea, Scafetta Giorgia, Di Napoli Arianna, Krasniqi Eriseld, Pizzuti Laura, Barba Maddalena, Carpano Silvia, Vici Patrizia, Fanciulli Maurizio, De Nicola Francesca, Ciuffreda Ludovica, Goeman Frauke, De Maria Ruggero, Vecchione Andrea, Giusti Raffaele, Ciliberto Gennaro, Marchetti Paolo, Maugeri-Saccà Marcello
Abstract excerpt
BACKGROUND: Immune checkpoint inhibitors (ICIs) provide significant survival benefits in non-small cell lung cancer (NSCLC). Nevertheless, while some patients obtain a prolonged benefit, a non-negligible fraction of patients experiences an ultrarapid disease progression. Identifying specific molecular backgrounds predicting opposite outcomes is instrumental to optimize the use of these agents in clinical...
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