Article

Investigating the mechanisms of influenza polymerase host adaptation

2014-01-01

Abstract excerpt

An avian virus can become adapted to humans by mutating or recombining with currently circulating human viruses. These viruses have the potential to cause pandemics in an immunologically naïve human population. Host restriction involves multiple determinants, however, influenza polymerase is considered to play an important role. The heterotrimeric polymerase complex (PA, PB1 and PB2) associates with viral RNA and...

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Literature Corpus work: 81bb14ce-47f6-536e-baa6-e0f1251c0aa5
DOI: 10.25560/24754

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