Article
Novel Polymerase Gene Mutations for Human Adaptation in Clinical Isolates of Avian H5N1 Influenza Viruses.
PLoS pathogens - 1 Apr 2016
Arai Yasuha, Kawashita Norihito, Daidoji Tomo, Ibrahim Madiha S, El-Gendy Emad M, Takagi Tatsuya, Takahashi Kazuo, Suzuki Yasuo, Ikuta Kazuyoshi, Nakaya Takaaki, Shioda Tatsuo, Watanabe Yohei
Abstract excerpt
A major determinant in the change of the avian influenza virus host range to humans is the E627K substitution in the PB2 polymerase protein. However, the polymerase activity of avian influenza viruses with a single PB2-E627K mutation is still lower than that of seasonal human influenza viruses, implying that avian viruses require polymerase mutations in addition to PB2-627K for human adaptation. Here, we used a...
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