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The K526R substitution in viral protein PB2 enhances the effects of E627K on influenza virus replication

20 Nov 2014

Abstract excerpt

Host-adaptive strategies, such as the E627K substitution in the PB2 protein, are critical for replication of avian influenza A viruses in mammalian hosts. Here we show that mutation PB2-K526R is present in some human H7N9 influenza isolates, in nearly 80% of H5N1 human isolates from Indonesia and, in conjunction with E627K, in almost all seasonal H3N2 viruses since 1970. Polymerase complexes containing PB2-526R...

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PMID: 25409547
DOI: 10.1038/ncomms6509

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