Article

The molecular basis of host range restriction of avian influenza virus polymerases in mammalian hosts

2013-01-01

Abstract excerpt

Influenza A virus adaptation to humans is a rare but recurrent event that can result in a pandemic. The influenza polymerase, composed of the viral proteins PB1, PB2 and PA, is responsible for transcription and replication of the viral genome. Typical avian-origin influenza polymerases are restricted in human cells and polymerase subunit PB2 is particularly involved in this restriction. Residue 627 of PB2 is a glu...

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Literature Corpus work: 828c4dd7-2cd3-551f-94d5-b9e699608560
DOI: 10.25560/10934

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