Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PA Mutations Inherited during Viral Evolution Act Cooperatively To Increase Replication of Contemporary H5N1 Influenza Virus with an Expanded Host Range.

Journal of virology - 9 Dec 2020

Arai Yasuha, Kawashita Norihito, Elgendy Emad Mohamed, Ibrahim Madiha Salah, Daidoji Tomo, Ono Takao, Takagi Tatsuya, Nakaya Takaaki, Matsumoto Kazuhiko, Watanabe Yohei

Abstract excerpt

Adaptive mutations and/or reassortments in avian influenza virus polymerase subunits PA, PB1, and PB2 are one of the major factors enabling the virus to overcome the species barrier to infect humans. The majority of human adaptation polymerase mutations have been identified in PB2; fewer adaptation mutations have been characterized in PA and PB1. Clade 2.2.1 avian influenza viruses (H5N1) are unique to Egypt and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chickens
Share to Egypt

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Host Specificity

Share to Influenza A Virus, H5N1 Subtype

Share to Orthomyxoviridae Infections

Share to RNA-Dependent RNA Polymerase

Share to Viral Nonstructural Proteins

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 33028722
DOI: 10.1128/JVI.01582-20
PMCID: PMC7737735

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PA Mutations Inherited during Viral Evolution Act Cooperatively To Increase Replication of Contemporary H5N1 Influenza Virus with an Expanded Host Range.PMID 33028722Read ↗

Prevailing PA Mutation K356R in Avian Influenza H9N2 Virus Increases Mammalian Replication and PathogenicitySemantic proximity Read ↗

Novel Polymerase Gene Mutations for Human Adaptation in Clinical Isolates of Avian H5N1 Influenza Viruses.Semantic proximity Read ↗

PB2-588 V promotes the mammalian adaptation of H10N8, H7N9 and H9N2 avian influenza virusesSemantic proximity Read ↗

PB2 mutations arising during H9N2 influenza evolution in the Middle East confer enhanced replication and growth in mammalsSemantic proximity Read ↗

The PB2 co‐adaptation of H10N8 avian influenza virus increases the pathogenicity to chickens and miceSemantic proximity Read ↗

Immediate PB2-E627K amino acid substitution after single infection of highly pathogenic avian influenza H5N1 clade 2.3.4.4b in miceSemantic proximity Read ↗

An evolutionary approach to identify mammalian adaptive mutations in the avian influenza polymerase complexSemantic proximity Read ↗

Multiple Natural Substitutions in Avian Influenza A Virus PB2 Facilitate Efficient Replication in Human CellsSemantic proximity Read ↗

Synergistic Effect of S224P and N383D Substitutions in the PA of H5N1 Avian Influenza Virus Contributes to Mammalian AdaptationSemantic proximity Read ↗

Prerequisites for the acquisition of mammalian pathogenicity by influenza A virus with a prototypic avian PB2 gene.Semantic proximity Read ↗

Enhanced genome replication activity of pandemic H1N1 influenza A virus through PA mutations.Semantic proximity Read ↗

Mutations in PB1, NP, HA, and NA Contribute to Increased Virus Fitness of H5N2 Highly Pathogenic Avian Influenza Virus Clade 2.3.4.4 in ChickensSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.