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Article

Evidence for Avian and Human Host Cell Factors That Affect the Activity of Influenza Virus Polymerase

15 Jul 2010

Abstract excerpt

Typical avian influenza A viruses do not replicate efficiently in humans. The molecular basis of host range restriction and adaptation of avian influenza A viruses to a new host species is still not completely understood. Genetic determinants of host range adaptation have been found on the polymerase complex (PB1, PB2, and PA) as well as on the nucleoprotein (NP). These four viral proteins constitute the minimal...

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PMID: 20631125
DOI: 10.1128/jvi.01134-10

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Evidence for Avian and Human Host Cell Factors That Affect the Activity of Influenza Virus PolymerasePMID 20631125Read ↗

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