Article
CD103+ intraepithelial T cells in high-grade serous ovarian cancer are phenotypically diverse TCRαβ+ CD8αβ+ T cells that can be targeted for cancer immunotherapy.
Oncotarget - 15 Nov 2016
Komdeur Fenne L, Wouters Maartje C A, Workel Hagma H, Tijans Aline M, Terwindt Anouk L J, Brunekreeft Kim L, Plat Annechien, Klip Harry G, Eggink Florine A, Leffers Ninke, Helfrich Wijnand, Samplonius Douwe F, Bremer Edwin, Wisman G Bea A, Daemen Toos, Duiker Evelien W, Hollema Harry, Nijman Hans W, de Bruyn Marco
Abstract excerpt
CD103+ tumor-infiltrating lymphocytes (TIL) have been linked to specific epithelial infiltration and a prolonged survival in high-grade serous epithelial ovarian cancer (HGSC). However, whether these cells are induced as part of an ongoing anti-HGSC immune response or represent non-specifically expanded resident or mucosal lymphocytes remains largely unknown. In this study, we first confirmed that CD103+ TIL from...
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