Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade.

doi:10.1136/jitc-2020-002231

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Article

Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade.

Journal for immunotherapy of cancer - 1 Apr 2021

Banchereau Romain, Chitre Avantika S, Scherl Alexis, Wu Thomas D, Patil Namrata S, de Almeida Patricia, Kadel Iii Edward E, Madireddi Shravan, Au-Yeung Amelia, Takahashi Chikara, Chen Ying-Jiun, Modrusan Zora, McBride Jacqueline, Nersesian Rhea, El-Gabry Ehab A, Robida Mark D, Hung Jeffrey C, Kowanetz Marcin, Zou Wei, McCleland Mark, Caplazi Patrick, Eshgi Shadi Toghi, Koeppen Hartmut, Hegde Priti S, Mellman Ira, Mathews W Rodney, Powles Thomas, Mariathasan Sanjeev, Grogan Jane, O'Gorman William E

Abstract excerpt

BACKGROUND: CD8+ tissue-resident memory T (TRM) cells, marked by CD103 (ITGAE) expression, are thought to actively suppress cancer progression, leading to the hypothesis that their presence in tumors may predict response to immunotherapy. METHODS: Here, we test this by combining high-dimensional single-cell modalities with bulk tumor transcriptomics from 1868 patients enrolled in lung and bladder cancer clinical...

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Identifiers

PMID: 33827905
DOI: 10.1136/jitc-2020-002231
PMCID: PMC8032254

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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