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Article

Active secretion of CXCL10 and CCL5 from colorectal cancer microenvironments associates with GranzymeB+ CD8+ T-cell infiltration.

Oncotarget - 20 Feb 2015

Zumwalt Timothy J, Arnold Mildred, Goel Ajay, Boland C Richard

Abstract excerpt

Transcriptional expression of CXCR3 and CCR5 cognate chemokines correlate with CD8+ T-cell infiltration and prolonged survival in colorectal cancer (CRC). These findings were derived mainly from paraffin embedded tissues; thus little is known about the secretion pattern of CD8+ T-cell targeting chemokines from CRCs. Therefore, we developed and introduced a novel platform that assesses the immune mediators that...

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Source

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Identifiers

PMID: 25671296
DOI: 10.18632/oncotarget.3205
PMCID: PMC4413778

Genes

CCL5
CCR5
CXCL10
CXCR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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