Article

Pharmacological GCase Activity Enhancement Inhibits Tau Accumulation

2024-08-13

Abstract excerpt

A slow decline in the autophagy-lysosomal pathway is a hallmark of the normal aging brain. Yet, an acceleration of this cellular function may propel neurodegenerative events. In fact, mutations in genes associated with the autophagy-lysosomal pathway can lead to Parkinson’s disease. Also, amyloidogenic protein deposition is observed in lysosomal storage disorders, which are caused by genetic mutations representing...

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Literature Corpus work: 37712fe3-77f9-5949-b571-c2322b63068d
DOI: 10.1101/2024.08.13.607706

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