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Article

Lysosomal dysfunction in α-synuclein pathology: molecular mechanisms and therapeutic strategies.

Cellular and molecular life sciences : CMLS - 3 Sept 2024

Dai Lijun, Liu Miao, Ke Wei, Chen Liam, Fang Xin, Zhang Zhentao

Abstract excerpt

In orchestrating cell signaling, facilitating plasma membrane repair, supervising protein secretion, managing waste elimination, and regulating energy consumption, lysosomes are indispensable guardians that play a crucial role in preserving intracellular homeostasis. Neurons are terminally differentiated post-mitotic cells. Neuronal function and waste elimination depend on normal lysosomal function. Converging...

Topics

Humans
Lysosomes
alpha-Synuclein
Parkinson Disease
Animals
Mutation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 39223418
DOI: 10.1007/s00018-024-05419-5
PMCID: PMC11368888

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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