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Article

The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease.

Brain : a journal of neurology - 1 Aug 2008

Pan Tianhong, Kondo Seiji, Le Weidong, Jankovic Joseph

Abstract excerpt

The ubiquitin-proteasome system (UPS) and autophagy-lysosome pathway (ALP) are the two most important mechanisms that normally repair or remove abnormal proteins. Alterations in the function of these systems to degrade misfolded and aggregated proteins are being increasingly recognized as playing a pivotal role in the pathogenesis of many neurodegenerative disorders such as Parkinson's disease. Dysfunction of the...

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Identifiers

PMID: 18187492
DOI: 10.1093/brain/awm318

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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