Article

The metalloproteases ADAM17 and ADAM10 regulate endothelial migration and proliferation induced by the mechanoresponsive ion channels Piezo1 and TRPV4

2025-05-29

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Endothelial cells are constantly exposed to mechanical forces generated by blood flow that regulate endothelial homeostasis. Pathological events such as vascular injury or thrombus formation alter these forces, which are sensed by endothelial cells and can trigger repair mechanisms, including inflammation, proliferation and migration. These mechanical changes...

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Literature Corpus work: 81969297-45f6-5c9f-9814-ba79b6ababa9
DOI: 10.21203/rs.3.rs-6751688/v1

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