Article
TRPV4 channel activation induces the transition of venous and arterial endothelial cells toward a pro-inflammatory phenotype.
Physiological reports - 1 Feb 2021
Beddek Kathia, Raffin Florent, Borgel Delphine, Saller François, Riccobono Diane, Bobe Régis, Boittin François-Xavier
Abstract excerpt
The Transient Receptor Potential Vanilloid 4 (TRPV4) of endothelial cells contributes to many important functions including the regulation of Ca2+ homeostasis, cell volume, endothelial barrier permeability, and smooth muscle tone. However, its role in the transition of endothelial cells toward a pro-inflammatory phenotype has not been studied so far. Using both arterial and venous endothelial cells, we first show...
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