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Yolk sac cell atlas reveals multiorgan functions during human early development

17 Aug 2023

Abstract excerpt

The extraembryonic yolk sac (YS) ensures delivery of nutritional support and oxygen to the developing embryo but remains ill-defined in humans. We therefore assembled a comprehensive multiomic reference of the human YS from 3 to 8 postconception weeks by integrating single-cell protein and gene expression data. Beyond its recognized role as a site of hematopoiesis, we highlight roles in metabolism, coagulation,...

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PMID: 37590359
DOI: 10.1126/science.add7564

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