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The NADPH oxidase NOX2 is a marker of adverse prognosis involved in chemoresistance of Acute Myeloid Leukemias

2021-03-04

Abstract excerpt

Resistance to chemotherapeutic drugs is a major cause of treatment failure in Acute Myeloid Leukemias (AML). To better characterize the mechanisms of chemoresistance, we first identified genes whose expression is dysregulated in AML cells resistant to daunorubicin (DNR) or cytarabine (Ara-C), the main drugs used for the induction therapy. The genes found activated are mostly linked to immune signaling and inflamma...

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Literature Corpus work
817d6bc5-5438-5822-9c66-815d0f424f52
DOI
10.1101/2021.03.04.433871
Open publication

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The NADPH oxidase NOX2 is a marker of adverse prognosis involved in chemoresistance of Acute Myeloid LeukemiasDOI 10.1101/2021.03.04.433871
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