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Mutations of methionine 444 interacting with T1Cu-coordinating amino acids affect the structure and function of multicopper oxidase CopA

2024-07-03

Abstract excerpt

<title>Abstract</title> <p>Manganese is an essential trace element for humans, animals, and plants, but excessive amounts of manganese can cause serious harm to organisms. The biological manganese oxidation process mainly oxidizes Mn(II) through the secretion of unique manganese oxidase by manganese-oxidizing bacteria. The T1 Cu site of multicopper oxidase is the main site for substrate oxidation, and its role is...

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Literature Corpus work
816920a5-5f61-593e-b7cc-b0f924131065
DOI
10.21203/rs.3.rs-4553086/v1
Open publication

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