Article
Mutations of methionine 444 interacting with T1Cu-coordinating amino acids affect the structure and function of multicopper oxidase CopA.
Biodegradation - 29 Oct 2024
Tang Wenwei, Zhang Peiqi, Jin Xiaoyu, Li Xiaorong, Chen Shichao, Zeng Xinping
Abstract excerpt
Manganese is an essential trace element for humans, animals, and plants, but excessive amounts of manganese can cause serious harm to organisms. The biological manganese oxidation process mainly oxidizes Mn(II) through the secretion of unique manganese oxidase by manganese-oxidizing bacteria. The T1 Cu site of multicopper oxidase is the main site for substrate oxidation, and its role is to transfer electrons to...
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