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Article

Cu+-specific CopB transporter: Revising P1B-type ATPase classification.

Proceedings of the National Academy of Sciences of the United States of America - 27 Feb 2018

Purohit Rahul, Ross Matthew O, Batelu Sharon, Kusowski April, Stemmler Timothy L, Hoffman Brian M, Rosenzweig Amy C

Abstract excerpt

The copper-transporting P1B-ATPases, which play a key role in cellular copper homeostasis, have been divided traditionally into two subfamilies, the P1B-1-ATPases or CopAs and the P1B-3-ATPases or CopBs. CopAs selectively export Cu+ whereas previous studies and bioinformatic analyses have suggested that CopBs are specific for Cu2+ export. Biochemical and spectroscopic characterization of Sphaerobacter...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29440418
DOI: 10.1073/pnas.1721783115
PMCID: PMC5834730

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