Sequence-based Functional Metagenomics Reveals Novel Natural Diversity of Functional CopA in Environmental Microbiomes.

doi:10.1016/j.gpb.2022.08.006

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Article

Sequence-based Functional Metagenomics Reveals Novel Natural Diversity of Functional CopA in Environmental Microbiomes.

Genomics, proteomics & bioinformatics - 1 Dec 2023

Li Wenjun, Wang Likun, Li Xiaofang, Zheng Xin, Cohen Michael F, Liu Yong-Xin

Abstract excerpt

Exploring the natural diversity of functional genes/proteins from environmental DNA in high throughput remains challenging. In this study, we developed a sequence-based functional metagenomics procedure for mining the diversity of copper (Cu) resistance gene copA in global microbiomes, by combining the metagenomic assembly technology, local BLAST, evolutionary trace analysis (ETA), chemical synthesis, and...

Topics

Metagenomics
Bacterial Proteins
Phylogeny
Microbiota
Copper
Metagenome
Escherichia coli
Genetic Variation

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Identifiers

PMID: 36089219
DOI: 10.1016/j.gpb.2022.08.006
PMCID: PMC11082258

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