The functional roles of the three copper sites associated with the methionine-rich insert in the multicopper oxidase CueO from E. coli.

Abstract excerpt

CueO from Escherichia coli is a multicopper oxidase (MCO) involved in copper tolerance under aerobic conditions. It features the four typical copper atoms that act as electron transfer (T1) and dioxygen reduction (T2, T3; trinuclear) sites. In addition, it displays a methionine- and histidine-rich insert that includes a helix that blocks physical access to the T1 site. In crystalline form, the insert provides at...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Binding Sites
• Share to Copper
• Share to Escherichia coli